I had issue on my air cooled BMW which was misfiring at low RPM and dropping down to one cylinder, I changed the plugs which cured it but it came back within 100 miles. Another new set of plugs cured it again but the same problem came back. In the end I found out the coil was breaking down and replaced the unit and all was fine. So I would suggest it is not failing plugs but something more serious within the magneto.
I have never had a spark plug fail in normal service, as for fuel my cheapo supermarket unleaded sat in the bike over the winter and it started 2nd kick when I dragged it out of the shed. Well worth getting your magneto tested I would think