Mike,
It's always great to hear of a completed restoration. Congrats. Also, welcome to the forum. If you get a chance, a few photos of your bike and a bit about how you came to be an "A"ppreciator are always interesting.
Regarding "knocking", we are all assuming you mean of the ignition type. If it is, indeed, ignition knocking you mean, maybe the problem is fuel octane. You haven't mentioned what pistons you have. Regardless, if you are not using premium fuel and, maybe, a lead substitute, you should give that a try (in addition to heeding the good advice given about timing).
Richard L.
Edit: Well, I see you did say "timing or mixture", so, equating to ignition "knocking". Sorry for my confusion.