If they’re in an area a seal operates, they do matter – they’re relatively deep. What caused them? I’ve no idea – they’re unevenly spaced and uni-directional – maybe the stanchion got caught up in some machinery where it shouldn’t have been. If you plan on filling them, I’d drill each a little deeper (but not right through!) to give the filler some purchase, rather like a dentist does. Devcon plastic steel would be my choice.